The optimal preemptive dose of gabapentin following gynecologic surgery / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 309-312, 2009.
Article
in Korean
| WPRIM
| ID: wpr-104660
ABSTRACT
BACKGROUND:
Gabapentin decreases acute nociceptive pain in animal and human studies when given before surgical incision. Various doses of gabapentin have been used (300-1,200 mg) to measure this preemptive effect. Here, we evaluated the optimal dose of gabapentin for reducing fentanyl consumption and the adverse effects of gabapentin following gynecologic surgery.METHODS:
We recruited 100 patients who underwent laparotomy for gynecologic surgery. Patients were randomly divided into 4 groups and received a placebo (control), gabapentin 300 mg (G 300), gabapentin 600 mg (G 600), or gabapentin 1,200 mg (G 1200) 2 h before surgery. Postoperatively, patients received fentanyl via an intravenous patient controlled analgesia device. The cumulative fentanyl doses were recorded 2, 6, 12, 24 h, and 48 h postoperatively, and the sedation scale was recorded in the post anesthetic care unit (PACU).RESULTS:
The postoperative fentanyl requirement was lower with gabapentin treatment, but there was no significant differences for the different doses. PACU sedation scores were not different in any group.CONCLUSIONS:
Gabapentin has a preemptive effect in gynecologic surgery, but there were no additional fentanyl-sparing benefits at doses above 300 mg. Thus, 300 mg is an optimal dose for decreasing fentanyl consumption following gynecologic surgery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Gynecologic Surgical Procedures
/
Fentanyl
/
Analgesia, Patient-Controlled
/
Cyclohexanecarboxylic Acids
/
Nociceptive Pain
/
Gamma-Aminobutyric Acid
/
Amines
/
Laparotomy
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2009
Type:
Article
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