Various Ocular MR Imagings in a Mouse Implanted with a New Cell Line of Retinoblastoma and the Correlation with the Pathology: Preliminary Study
Journal of the Korean Radiological Society
;
: 431-437, 2007.
Article
in Korean
| WPRIM
| ID: wpr-104718
ABSTRACT
PURPOSE:
We wanted to show various MR and correlated pathologic images of retinoblastoma in nude mousewith a new human retinoblastom cell line (SNUOT-Rb1), which was inoculated into the intravitreous cavity. MATERIALS ANDMETHODS:
The established cell line was inoculated into the intravitreous cavity of 36 eyeballs of 18 mice and the transplanted retinoblastoma was examined for 3 months. The T1-weighted (T1WI), T2-weighted (T2WI), and contrast enhanced (Gd-DTPA) T1-weighted images were obtained with using a small loop coil. After scanning, the mice's eyeballs were extracted and the hematoxylin & eosin stained specimens were examined with a microscope. We compared the MR imagings with pathologic findings and evaluated the character of the tumors.RESULTS:
The innoculated cells in the eyeballs of the mice grew into retinoblastoma (23/36, 64%). The eyeballs with retinoblastoma protruded externally and showed focal hemorrhage. Most tumors showed iso-signal intensity on TIWI (13/23, 57%), high signal intensity on T2WI (17/23, 74%), and good enhancement (21/23, 91%) with contrast. Almost all of the tumors (n=21) were located in the retina and three extraretinal tumors were confirmed by pathology. Involvement of the optic nerve was suspected on MRI and this was confirmed by pathology in 6 cases and 5 cases, respectively.CONCLUSION:
We could demonstrate various MR imagings of transplanted retinoblastoma by using the new tumor cell line in vivo.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Optic Nerve
/
Pathology
/
Retina
/
Retinoblastoma
/
Magnetic Resonance Imaging
/
Cell Line
/
Eosine Yellowish-(YS)
/
Cell Line, Tumor
/
Hematoxylin
/
Hemorrhage
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Journal of the Korean Radiological Society
Year:
2007
Type:
Article
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