Cloning a new allele form of bovine TNF-alpha
Journal of Veterinary Science
;
: 139-141, 2001.
Article
in English
| WPRIM
| ID: wpr-104742
ABSTRACT
Although little is known on the function of gammadelta T lymphocytes, there is increasing evidence that gammadelta T lymphocytes are early responders and modulators of immune responses against pathogens and cytokines such as IL-2, IL-7, IL-15 and TNF-alpha. To study the role TNF-alpha on gammadelta T lymphocytes, we cloned bovine TNF-alpha. Sequence analysis revealed that a new allele form of bovine TNF-alpha was cloned which has 3 additional nucleotide sequences as well as 3 nucleotide substitutions compared with previously reported bovine TNF-alpha. Further studies are needed to document the functional significance of a new allele form of TNF-alpha in cattle.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Molecular Sequence Data
/
Base Sequence
/
T-Lymphocytes
/
Gene Library
/
Sequence Alignment
/
Amino Acid Sequence
/
Tumor Necrosis Factor-alpha
/
Receptors, Antigen, T-Cell, gamma-delta
/
Cloning, Molecular
/
Alleles
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2001
Type:
Article
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