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The Association between Psoriasis Area and Severity Index and Cardiovascular Risk Factor in Korean Psoriasis Patients
Annals of Dermatology ; : 360-363, 2016.
Article in English | WPRIM | ID: wpr-105044
ABSTRACT

BACKGROUND:

Psoriasis is associated with increased risk of cardiovascular morbidities, especially in severe cases. Severity of the disease has been known to be associated with higher prevalence of these risk factors. However, in the absence of robust measurements, studies to date relied mostly on treatment spectrum as a proxy for the severity.

OBJECTIVE:

To evaluate the relationship between psoriasis area and severity index (PASI) and cardiovascular risk factors in Korean patients.

METHODS:

Presence of diabetes mellitus (DM), hypertension, smoking history was surveyed through questionnaires and serum lipid profile analysis were done after fasting overnight. The severity of psoriasis was assessed using PASI scores mild, <10; moderate to severe, ≥10. Cardiovascular risk factors such as smoking, hypertension, diabetes and dyslipidemia were compared between the mild group and moderate to severe group. The prevalence of diabetes and hypertension was compared among these two groups of psoriasis patients and the general population based control; age and gender were matched among three groups accordingly prior to analysis.

RESULTS:

A total of 256 patients with plaque type psoriasis were included. Between mild group and moderate to severe group, significant differences of cardiovascular risk factors including lipid profile were not discovered except in triglyceride level. Comparing to general population, prevalence of diabetes was found significantly higher in psoriasis patients while that of hypertension was similar.

CONCLUSION:

Our results suggest that among cardiovascular risks, presence of DM and triglyceride level seem to be associated with the presence of psoriasis in Korean psoriasis patients, while other factors may not contribute meaningfully.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Psoriasis / Smoke / Triglycerides / Smoking / Prevalence / Risk Factors / Fasting / Proxy / Diabetes Mellitus / Dyslipidemias Type of study: Etiology study / Prevalence study / Risk factors Limits: Humans Language: English Journal: Annals of Dermatology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Psoriasis / Smoke / Triglycerides / Smoking / Prevalence / Risk Factors / Fasting / Proxy / Diabetes Mellitus / Dyslipidemias Type of study: Etiology study / Prevalence study / Risk factors Limits: Humans Language: English Journal: Annals of Dermatology Year: 2016 Type: Article