Ampelopsis japonica Makino Extract Inhibits the Inflammatory Reaction Induced by Pathogen-Associated Molecular Patterns in Epidermal Keratinocytes
Annals of Dermatology
;
: 352-359, 2016.
Article
in English
| WPRIM
| ID: wpr-105045
ABSTRACT
BACKGROUND:
Keratinocytes are the major cells in epidermis, providing barrier components such as cornified cells through the sophisticated differentiation process. In addition, keratinocytes exerts their role as the defense cells via activation of innate immunity. It has been known that pathogen-associated molecular patterns (PAMPs) including double-strand RNA and nucleotides can provoke inflammatory reaction in keratinocytes.OBJECTIVE:
The aim of this study is to evaluate the effect of Ampelopsis japonica Makino extract (AE) on PAMPs-induced inflammatory reaction of keratinocytes.METHODS:
The effects of AE were determined using poly (IC)-induced inflammation and imiquimod-induced psoriasiform dermatitis models.RESULTS:
In cultured keratinocytes, AE significantly inhibited poly(IC)-induced expression of inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor-α. AE significantly inhibited poly(IC)-induced release of caspase-1 active form (p20), and down-regulated nuclear factor-κB signaling pathway. In imiquimod-induced psoriasiform dermatitis model, topical application of AE resulted in significant reduction of epidermal hyperplasia.CONCLUSION:
These results suggest that AE may be a potential candidate for the treatment of skin inflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
RNA
/
Keratinocytes
/
Cytokines
/
Interleukin-8
/
Interleukins
/
Interleukin-6
/
Ampelopsis
/
Dermatitis
/
Epidermis
Type of study:
Prognostic study
Language:
English
Journal:
Annals of Dermatology
Year:
2016
Type:
Article
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