Histomorphometric evaluation of bone healing with natural calcium carbonatederived bone substitutes in rat calvarial defect / 대한치주과학회지
The Journal of the Korean Academy of Periodontology
;
: 83-90, 2008.
Article
in Korean
| WPRIM
| ID: wpr-105075
ABSTRACT
PURPOSE:
This study investigated the osteoconductivity of natural calcium carbonate-derived bone substitutes, hen eggshell (ES), and compared with those of commercial bone substitutes. MATERIALS ANDMETHODS:
Osseous defects created in the rat calvaria were filled with particulated ES(ES-1), ES with calcium-deficient hydroxyapatite surface layer (ES-2), Biocoral(Inoteb, France), and Bio-Oss(Geistlich Pharma, Wolhusen, Switzerland). After 4 and 8 weeks of healing, histomorphometic analysis was performed to evaluate the amount of newly formed mineralized bone area (NB%).RESULTS:
Histologic and histomorphometric analysis showed new bone formation and direct bony contact with the grafted materials in all groups. At 4 weeks, Biocoral group showed greater NB% compared to Bio-Oss and ES-1 groups (P<0.05). At 8 weeks, Biocoral and ES-2 groups showed significantly greater NB% compared to Bio-Oss group (P<0.05).CONCLUSION:
These results indicate that natural calcium carbonate-derived bone substitutes with microporous calciumdeficient hydroxyapatite surface layer may be an effective materials treating osseous defects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Skull
/
Calcium Carbonate
/
Calcium
/
Durapatite
/
Bone Substitutes
/
Transplants
/
Minerals
Limits:
Animals
Language:
Korean
Journal:
The Journal of the Korean Academy of Periodontology
Year:
2008
Type:
Article
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