Hepatic Parenchymal Changes After Percutaneous Injection of Holmium-166 in Rabbit
Journal of the Korean Society of Magnetic Resonance in Medicine
;
: 43-48, 2001.
Article
in Korean
| WPRIM
| ID: wpr-105087
ABSTRACT
PURPOSE:
To evaluate changes in rabbit liver parenchyma on MR images following percutaneous Holmium-166 injection, and to correlate those changes with histologic findings. MATERIALS ANDMETHODS:
Holmium-166 (10-25 mCi) was percutaneously injected into the liver of rabbit (n=12) under sonographic guidance. MR images were obtained between one to two weeks (acute phase) after the injection in four rabbits, and between two to four weeks (subacute phase) after the injection in four rabbits. Tissue specimens of these eight rabbits were obtained immediately after MR imaging. Tissue specimens were obtained without MR imaging in four rabbits (between one to two weeks in one rabbit and between three to four weeks in three rabbits).RESULTS:
Tissue specimens showed central liquefactive necrosis and peripheral coagulative necrosis containing deposition of small particles and hemorrhage. The peripheral margin of the lesions showed formation of the granulation tissue with fibrosis, which tended to be more prominent in subacute phase. The area of the necrosis tended to correlate with the dose of the radioactive Holmium-166. On MR images, the central portion of the necrosis showed hyperintensity on T2-weighted image, hypointensity on the precontrast T1-weighted images, and no enhancement on the dynamic MR images. The peripheral portion of the necrosis showed hypointensity on T2-weighted images, iso or mild hypointensity on the T1-weighted images, and mild peripheral enhancement on the delayed dynamic MR images. The peripheral margin of the lesion showed hypointensity on both T1- and T1-weighted images with increased enhancement on the delayed phase images of the dynamic MR images.CONCLUSION:
After percutaneous Holmium-166 injection into rabbit liver parenchyma, the central portion showed liquefactive necrosis, the peripheral portion showed coagulative necrosis with granulation, fibrosis, hemorrhage and depostition of small granules. MR imaging may be helpful in evaluation of the histological change of the liver after percutaneous Holmium-166 treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Fibrosis
/
Magnetic Resonance Imaging
/
Ultrasonography
/
Granulation Tissue
/
Hemorrhage
/
Liver
/
Necrosis
Type of study:
Diagnostic study
/
Practice guideline
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Society of Magnetic Resonance in Medicine
Year:
2001
Type:
Article
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