Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging
Dementia and Neurocognitive Disorders
;
: 61-67, 2016.
Article
in English
| WPRIM
| ID: wpr-105260
ABSTRACT
Apolipoprotein E is a plasma protein that has an important role in transport and metabolism of lipids in serum as well as central nervous system. Among the 3 common alleles, the ε2 allele has the most stable structure followed by ε3 and ε4 in order. There is evidence for a deleterious role of ε4 allele by atherosclerosis and amyloid beta accumulation in brain and body. The presence and gene dose of ε4 allele are risk factors for late-onset Alzheimer's disease. Apolipoprotein E ε4 may have a role in the pathology of amyloid beta and tau and it has a strong relationship with the early onset of late-onset Alzheimer's disease. However, early-onset Alzheimer's disease has a weaker relationship with ε4 allele of apolipoprotein E.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Apolipoproteins
/
Plasma
/
Brain
/
Central Nervous System
/
Risk Factors
/
Alleles
/
Atherosclerosis
/
Apolipoprotein E4
/
Alzheimer Disease
Type of study:
Etiology study
/
Risk factors
Language:
English
Journal:
Dementia and Neurocognitive Disorders
Year:
2016
Type:
Article
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