Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion before and during cisplatin chemotherapy in patients with intrathoracic malignancy / 결핵
Tuberculosis and Respiratory Diseases
;
: 811-816, 1999.
Article
in Korean
| WPRIM
| ID: wpr-105662
ABSTRACT
BACKGROUND:
Nausea and vomiting associated with chemotherapy are common side effects which remain difficult to control. Acute phase nausea and vomiting (0-24 hours after induction of chemotherapy) parallels plasma serotonin release, which explains the effectiveness of 5-HT3 receptor antagonists. Serotonin released from gastrointestinal enterochromaffin cells may mediate chemotherapy-induced emesis. In this study, we analyzed urinary excretion of 5-HIAA, the main metabolite of serotonin.METHODS:
Eight men and four women were studied in their cisplatin chemotherapy cycle. Urinary 5-hydroxyindoleacetic aicd (HIAA) levels were determined before and during a 24-hour period under ondansetron prophylaxis.RESULTS:
Urinary 5-HIAA excretion for a 24-hour period was increased in all patients after induction of cisplatin (P=0.002).CONCLUSION:
Cisplatin chemotherapy is associated with serotonin release in the acute phase. Our finding provides evidence for a relationship between emesis and serotonin following cisplatin chemotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Vomiting
/
Serotonin
/
Cisplatin
/
Ondansetron
/
Receptors, Serotonin, 5-HT3
/
Drug Therapy
/
Enterochromaffin Cells
/
Hydroxyindoleacetic Acid
/
Nausea
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS