Effects of natural eggshell membrane (NEM) on monosodium iodoacetate-induced arthritis in rats / 한국영양학회지
Journal of Nutrition and Health
;
: 310-318, 2015.
Article
in Korean
| WPRIM
| ID: wpr-10567
ABSTRACT
PURPOSE:
The aim of this study is to investigate anti-arthritis activity using natural eggshell membrane (NEM).METHODS:
NEM was administered at 52 mg/kg, 200 mg/kg, and 400 mg/kg to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 3 mg. NO production in serum was measured using Griess reagent. Cytokines including IL-1beta, and IL-6 were measured by Luminex and PGE2, MMP-2, MMP-9, TIMP-1, LTB4, and hs-CRP were measured by ELISA. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system.RESULTS:
Production of NO, IL-1beta, IL-6, PGE2, MMP-2, MMP-9, TIMP-1, LTB4, and hs-CRP in serum was decreased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the NEM group showed a decrease in the cartilage of patella, synovial membrane, and transformation of fibrous tissue.CONCLUSION:
The results for NEM showed significant anti-arthritis activity. These results may be developed as a raw material for new health food to ease the symptoms mentioned above.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoarthritis
/
Patella
/
Arthritis
/
Synovial Membrane
/
Enzyme-Linked Immunosorbent Assay
/
Dinoprostone
/
Cartilage
/
Cytokines
/
Interleukin-6
/
Leukotriene B4
Limits:
Animals
Language:
Korean
Journal:
Journal of Nutrition and Health
Year:
2015
Type:
Article
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