Protracted Venous Infusion of 5-Fluorouracil as a Chemotherapy in Colorectal Cancer / 대한암학회지
Journal of the Korean Cancer Association
;
: 120-125, 1999.
Article
in Korean
| WPRIM
| ID: wpr-105687
ABSTRACT
PURPOSE:
The administration of 5-fluorouracil (5-FU) by protracted intravenous infusion is an alternative to the bolus administration of 5-FU in patients with advanced colorectal cancers. This study was performed to evaluate the response rate and toxicities of protracted infusion of 5-FU in patients with advanced or recurrent colorectal cancers who had been treated with 5-FU by bolus or shortterm continuous administration. MATERIALS ANDMETHODS:
Between March 1995 and June 1997, twenty-eight patients with advanced colorectal cancer previously exposed to 5-FU based chemotherapy were enrolled in this triaL Patients received 5-FU (250 mg/m(2)/day days 1-28) or 5-FU plus leucovorin (5-FU; 200 mg/m/day days 1-28, leucovorin; 20 mg/m IV days 1, 8, 15, 21) by ambulatory infusion pump. Treatment course was repeated every 42 days until disease progression.RESULT:
Twenty-eight patients entered. All 28 patients were assessable for response and toxicity. Five (19%) patients achieved a partial response, with the median response duration of 15 weeks (range; 7-22 weeks), and median survival time of entire patients was 54 weeks (range 7-151+ weeks). Gastrointestinal toxicity, specifically stomatitis was a major toxicity (grade 2, 12%; grade 3, 4%), but hand-foot syndrome was less frequent (5%) compared with other trials with protracted infusion of 5-FU reported in the literature. Hematologic toxicity was generally of low grade.CONCLUSION:
Prolonged intravenous infusion of 5-FU can produce a response rate of 19% with low toxicity among patients refractory to bolus or short-term infusion of S-FU.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomatitis
/
Infusion Pumps
/
Infusions, Intravenous
/
Colorectal Neoplasms
/
Leucovorin
/
Disease Progression
/
Drug Therapy
/
Hand-Foot Syndrome
/
Fluorouracil
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Cancer Association
Year:
1999
Type:
Article
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