Premedication Methods in Nasal Endoscopy: A Prospective, Randomized, Double-Blind Study
Clinical and Experimental Otorhinolaryngology
;
: 158-163, 2017.
Article
in English
| WPRIM
| ID: wpr-10590
ABSTRACT
OBJECTIVES:
To identify the optimal pharmacological method of preparing patients for nasal endoscopy.METHODS:
Twenty healthy volunteers were enrolled in this prospective, randomized, double-blind study. Four types of medications were applied in their nostrils with binary combinations of spray bottles on four different days in a random order placebo (normal saline [NS]+NS), decongestant (NS+oxymetazoline), anesthetic (NS+lidocaine), and decongestant plus anesthetic (oxymetazoline+lidocaine). Rigid nasal endoscopy was performed 10 minutes after spray application. The volunteers evaluated the discomfort caused by each spray application, and nasal pain scores due to the passage of the endoscope. The physicians quantified nasal decongestion using a visual analogue scale. Endoscopy duration as well as pulse and mean blood pressure (MBP) before spray application, 10 minutes after the application, and immediately after endoscopic examination were also recorded.RESULTS:
The discomfort caused by lidocaine was significantly higher than that caused by the other sprays (P<0.001). The lowest pain score related to endoscopy was obtained for oxymetazoline+lidocaine (P<0.001). Nasal decongestion was best achieved with NS+oxymetazoline (P<0.001). Endoscopy duration was the shortest for oxymetazoline+ lidocaine (P<0.05). Statistically significant MBP changes were only seen with the application of NS+oxymetazoline (P<0.05). However, neither MBP nor pulse rate change was significant clinically.CONCLUSION:
Application of decongestant and anesthetic sprays together seems to be the best method of pharmacological preparation of patients for nasal endoscopy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxymetazoline
/
Premedication
/
Nasal Decongestants
/
Volunteers
/
Blood Pressure
/
Double-Blind Method
/
Prospective Studies
/
Endoscopes
/
Endoscopy
/
Healthy Volunteers
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Clinical and Experimental Otorhinolaryngology
Year:
2017
Type:
Article
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