Avoiding or coping with severe hypoglycemia in patients with type 2 diabetes
The Korean Journal of Internal Medicine
;
: 6-16, 2015.
Article
in English
| WPRIM
| ID: wpr-106142
ABSTRACT
Hypoglycemia is a major barrier to achieving the glycemic goal in patients with type 2 diabetes. In particular, severe hypoglycemia, which is defined as an event that requires the assistance of another person to actively administer carbohydrates, glucagon, or take other corrective actions, is a serious clinical concern in patients with diabetes. If severe hypoglycemia is not managed promptly, it can be life threatening. Hypoglycemia-associated autonomic failure (HAAF) is the main pathogenic mechanism behind severe hypoglycemia. Defective glucose counter-regulation (altered insulin secretion, glucagon secretion, and an attenuated increase in epinephrine during hypoglycemia) and a lack of awareness regarding hypoglycemia (attenuated sympathoadrenal activity) are common components of HAAF in patients with diabetes. There is considerable evidence that hypoglycemia is an independent risk factor for cardiovascular disease. In addition, hypoglycemia has a significant influence on the quality of life of patients with diabetes. To prevent hypoglycemic events, the setting of glycemic goals should be individualized, particularly in elderly individuals or patients with complicated or advanced type 2 diabetes. Patients at high-risk for the future development of severe hypoglycemia should be selected carefully, and intensive education with reinforcement should be implemented.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Autonomic Nervous System
/
Blood Glucose
/
Biomarkers
/
Health Knowledge, Attitudes, Practice
/
Patient Education as Topic
/
Incidence
/
Prevalence
/
Risk Factors
/
Risk Assessment
Type of study:
Etiology study
/
Incidence study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2015
Type:
Article
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