Risk Factors for Intrahepatic Recurrence
Korean Journal of Hepato-Biliary-Pancreatic Surgery
;
: 83-89, 2011.
Article
in English
| WPRIM
| ID: wpr-106192
ABSTRACT
PURPOSE:
Although surgical resection offers patients with HCC the chance of a cure, the post-resection tumor recurrence rate is high, with reported cumulative 5-year tumor recurrence rates ranging from 40 to 70%. The objective of this study was to investigate risk factors for intrahepatic recurrence after resection of hepatocellular carcinoma, especially in patients with hepatitis B virus infection.METHODS:
Between January 1999 and December 2003, 59 patients in our Hospital with hepatitis B virus infection underwent liver resection for hepatocellular carcinoma. Clinical, biological, and histopathological characteristics of these patients were collected and tested for their prognostic significance using a Chi-square test and a Student's t-test. Time to recurrence and survival rate were analyzed by the Kaplan-Meier method.RESULTS:
Of the 59 patients who underwent liver resection, 24 (41%) experienced intrahepatic recurrence. The 1-, 3-, and 5-year overall survival rates of total enrolled patients were 83%, 63%, and 42%, respectively. The 1-, 3-, and 5-year overall survival rates after recurrence were 87%, 52%, and 20%, respectively. The risk factors for early recurrence were elevated serum aspartate aminotransferase (AST) level (p=0.044) and larger tumor size (p=0.049). For late recurrence, greater tumor size (p=0.039) was the only risk factor.CONCLUSION:
Tumor size and serum aspartate aminotransferase are risk factors of intrahepatic recurrence after resection of HCC in patients with chronic hepatitis B virus infection. This finding indicates that patients who have these risk factors should be under more careful supervision and have more aggressive follow-up.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organization and Administration
/
Aspartate Aminotransferases
/
Recurrence
/
Viruses
/
Hepatitis B virus
/
Survival Rate
/
Risk Factors
/
Follow-Up Studies
/
Carcinoma, Hepatocellular
/
Hepatitis B, Chronic
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Korean Journal of Hepato-Biliary-Pancreatic Surgery
Year:
2011
Type:
Article
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