Residual Cardiovascular Risk Remains Despite of Statin Treatment: Importance of High-Density Lipoprotein Cholesterol / 대한내과학회지
Korean Journal of Medicine
;
: 397-401, 2011.
Article
in Korean
| WPRIM
| ID: wpr-106254
ABSTRACT
Lowering low-density lipoprotein-cholesterol (LDL-C) is the primary target to prevent cardiovascular events in patients with dyslipidemia at high risk for cardiovascular disease. Many patients on statin therapy have initial or recurrent coronary heart disease events despite reductions in LDL-C. Indeed, 2/3 of patients on statin therapy suffer from residual risk. Low high-density lipoprotein-cholesterol (HDL-C) and high triglycerides levels are modifiable and important factors to resolve a residual risk. Especially, low serum levels of HDL-C (< 40 mg/dL for men, < 50 mg/dL for women) are highly prevalent and are recognized as an independent risk factor for cardiovascular morbidity (myocardial infarction, stroke, peripheral arterial disease, and restenosis after coronary stenting) and mortality. Thus, therapy focusing on raising HDL-C may be an important paradigm for treating and slowing progression of atherosclerosis, coronary heart disease, and co-morbid metabolic disorders. In this review, we discuss the importance of HDL-C based on experimental and large scaled clinical trials.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triglycerides
/
Coronary Artery Disease
/
Cardiovascular Diseases
/
Cholesterol
/
Risk Factors
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Coronary Disease
/
Stroke
/
Dyslipidemias
/
Peripheral Arterial Disease
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2011
Type:
Article
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