Comparison of ramosetron's and ondansetron's preventive anti-emetic effects in highly susceptible patients undergoing abdominal hysterectomy / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 488-492, 2011.
Article
in English
| WPRIM
| ID: wpr-106334
ABSTRACT
BACKGROUND:
This study compared the preventive effects of ramosetron and ondansetron on postoperative nausea and vomiting (PONV) in highly susceptible patients undergoing abdominal hysterectomy.METHODS:
In a prospective, randomized, double-blinded study, a total of 120 highly susceptible women (nonsmokers, those receiving opioid-based IV patient-controlled analgesia [PCA]) undergoing abdominal hysterectomy were included in the study. Patients were divided into 2 groups and each group received either 0.3 mg of ramosetron or 4 mg of ondansetron, IV. All patients received fentanyl-based IV PCA during the 48 h postoperative periods. The incidences of PONV and side effects of 5-HT3 antagonists (headache and dizziness) were assessed at 3 intervals (<2 h, 2-24 h and 24-48 h) postoperatively.RESULTS:
Patients in the ramosetron group showed a significantly higher ratio of complete response and lower incidence of nausea during the 24-48 h interval after surgery compared with those the ondansetron group.CONCLUSIONS:
Ramosetron (0.3 mg) is more effective in preventing delayed PONV in highly susceptible women undergoing abdominal hysterectomy compared with ondansetron (4 mg).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
Benzimidazoles
/
Passive Cutaneous Anaphylaxis
/
Incidence
/
Prospective Studies
/
Analgesia, Patient-Controlled
/
Ondansetron
/
Postoperative Nausea and Vomiting
/
Serotonin 5-HT3 Receptor Antagonists
/
Hysterectomy
Type of study:
Controlled clinical trial
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2011
Type:
Article
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