Effects of Hydro-Alcoholic Extract of Rhus coriaria (Sumac) Seeds on Reproductive Complications of Nicotinamide-Streptozotocin Induced Type-2 Diabetes in Male Mice
The World Journal of Men's Health
;
: 151-158, 2014.
Article
in English
| WPRIM
| ID: wpr-106557
ABSTRACT
PURPOSE:
The purpose of this study was to investigate the effects of the hydro-alcoholic extract of Rhus coriaria seeds on the reproductive system of nicotinamide-streptozotocin-induced type-2 diabetic mice. MATERIALS ANDMETHODS:
In this experimental study, 56 male Naval Medical Research Institute mice were randomly divided into seven groups (n=8) control; diabetic mice; diabetic mice administered glibenclamide (0.25 mg/kg); diabetic mice who received the hydro-alcoholic extract of R. coriaria seeds (200 and 400 mg/kg groups); and normal mice who received this extract (200 and 400 mg/kg groups). Diabetes was induced by intraperitoneal administration of streptozotocin (65 mg/kg) 15 minutes after an injection of nicotinamide (120 mg/kg). Then, glibenclamide and the above mentioned extract were administered orally for 28 consecutive days. Twenty-four hours after the last treatment, serum samples, the testes, and the cauda epididymis were removed immediately for hormonal, testis morphology, and sperm parameter assessments.RESULTS:
Body and testicular weight, sperm count and viability, and serum luteinizing hormone, follicle-stimulating hormone and testosterone levels were significantly lower in the diabetic mice (p<0.05). The diabetic mice treated with 400 mg/kg of the hydro-alcoholic extract of R. coriaria seeds recovered from these reductions (p<0.05). Further, glibenclamide alleviated hormonal and sperm count depletion in diabetes-induced mice (p<0.05).CONCLUSIONS:
The present results indicated that the hydro-alcoholic extract of R. coriaria seeds has anti-infertility effects in diabetic males.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sperm Count
/
Spermatogenesis
/
Spermatozoa
/
Testis
/
Testosterone
/
Luteinizing Hormone
/
Glyburide
/
Streptozocin
/
Niacinamide
/
Rhus
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
The World Journal of Men's Health
Year:
2014
Type:
Article
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