Reversibility of Ultrastructural Changes of Cultured Human Nasal Epithelial Cells Induced by Tumor Necrosis Factor-alpha
Journal of Rhinology
;
: 50-56, 1997.
Article
in English
| WPRIM
| ID: wpr-106718
ABSTRACT
Tumor necrosis factor (TNF)-alphacan induce ultrastructural changes in cultured human nasal epithelial cells. The aims of this study are to determine the recovery time from the changes induced by TNF-alphaand observe whether various degrees of changes will result in a complete return to normal status. The recovery of cilia was observed on the third day after cessation of adding TNF-alphaand the normalization of secretory cell area was observed on the fifth day. The morphologic changes induced by TNF-alpha were reversible except with the concentration of 100 ng/ml. The results suggest that the ultrastructural changes induced by TNF-alpha are mostly reversible and that this reversibility corresponds with the in vivo state.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cilia
/
Tumor Necrosis Factor-alpha
/
Epithelial Cells
Limits:
Humans
Language:
English
Journal:
Journal of Rhinology
Year:
1997
Type:
Article
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