Near-tetraploidy Acute Myeloid Leukemia with RUNX1-RUNX1T1 Rearrangement Due to Cryptic t(8;21) / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 510-514, 2009.
Article
in Korean
| WPRIM
| ID: wpr-106766
ABSTRACT
Tetraploidy or near-tetraploidy is a rare cytogenetic abnormality found in AML, and is divided into primary and secondary forms. The secondary tetraploidy or near-tetraploidy found in AML is known to be specifically associated with t(8;21). In this case report, FISH analysis detected RUNX1-RUNX1T1 gene rearrangement in the absence of cytogenetic abnormality of t(8;21), which suggests the presence of unvailed t(8;21). This is the first case report of tetraploidy or near-tetraploidy AML with cryptic RUNX1/RUNX1T1 in Korea. Although the prognosis of tetraploidy or near- tetraploidy with t(8;21) is known to be poor, this patient shows a relatively good clinical course compared to other reported cases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyploidy
/
Transcription Factors
/
Translocation, Genetic
/
Chromosomes, Human, Pair 8
/
Chromosomes, Human, Pair 21
/
Gene Rearrangement
/
Leukemia, Myeloid, Acute
/
Proto-Oncogene Proteins
/
In Situ Hybridization, Fluorescence
/
Core Binding Factor Alpha 2 Subunit
Type of study:
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
Korean
Journal:
The Korean Journal of Laboratory Medicine
Year:
2009
Type:
Article
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