Your browser doesn't support javascript.
loading
Safety of reduced dose of mycophenolate mofetil combined with tacrolimus in living-donor liver transplantation
Clinical and Molecular Hepatology ; : 291-299, 2014.
Article in English | WPRIM | ID: wpr-106796
ABSTRACT
BACKGROUND/

AIMS:

The dose of mycophenolate mofetil (MMF) has been reduced in Asia due to side effects associated with the conventional fixed dose of 2-3 g/day. We aimed to determine the pharmacokinetics of a reduced dose of MMF and to validate its feasibility in combination with tacrolimus in living-donor liver transplantation (LDLT).

METHODS:

Two sequential studies were performed in adult LDLT between October 2009 and 2011. First, we performed a prospective pharmacokinetic study in 15 recipients. We measured the area under the curve from 0 to 12 hours (AUC0-12) for mycophenolic acid at postoperative days 7 and 14, and we performed a protocol biopsy before discharge. Second, among 215 recipients, we reviewed 74 patients who were initially administered a reduced dose of MMF (1.0 g/day) with tacrolimus (trough, 8-12 ng/mL during the first month, and 5-8 ng/mL thereafter), with a 1-year follow-up. We performed protocol biopsies at 2 weeks and 1 year post-LDLT.

RESULTS:

In the first part of study, AUC0-12 was less than 30 mgh/L in 93.3% of cases. In the second, validating study, 41.9% of the recipients needed dose reduction or cessation due to side effects within the first year after LDLT. At 12 months post-LDLT, 17.6% of the recipients were administered a lower dose of MMF (0.5 g/day), and 16.2% needed permanent cessation due to side effects. The 1- and 12-month rejection-free survival rates were 98.6% and 97.3%, respectively.

CONCLUSIONS:

A reduced dose of MMF was associated with low blood levels compared to the existing recommended therapeutic range. However, reducing the dose of MMF combined with a low level of tacrolimus was feasible clinically, with an excellent short-term outcome in LDLT.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Retrospective Studies / ROC Curve / Follow-Up Studies / Liver Transplantation / Tacrolimus / Liver Failure / Area Under Curve / Drug Therapy, Combination / Gastrointestinal Diseases Type of study: Practice guideline / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Clinical and Molecular Hepatology Year: 2014 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Retrospective Studies / ROC Curve / Follow-Up Studies / Liver Transplantation / Tacrolimus / Liver Failure / Area Under Curve / Drug Therapy, Combination / Gastrointestinal Diseases Type of study: Practice guideline / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Clinical and Molecular Hepatology Year: 2014 Type: Article