Factors affecting drug-induced liver injury: antithyroid drugs as instances
Clinical and Molecular Hepatology
;
: 237-248, 2014.
Article
in English
| WPRIM
| ID: wpr-106803
ABSTRACT
Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxicity induced by these drugs. The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents. Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage. An outline on the clinically used treatments for antithyroid drugs-induced hepatotoxicity and the potential therapeutic strategies found to be effective against this complication are also discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antithyroid Agents
/
Graves Disease
/
Risk Factors
/
Reactive Oxygen Species
/
Protective Agents
/
Disease Models, Animal
/
Chemical and Drug Induced Liver Injury
/
Hyperthyroidism
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Animals
/
Humans
Language:
English
Journal:
Clinical and Molecular Hepatology
Year:
2014
Type:
Article
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