Histologic Characteristics in the Eyes of DBA/2J Mice according to the Degree of Intraocular Pressure
Journal of the Korean Ophthalmological Society
;
: 1547-1553, 2004.
Article
in Korean
| WPRIM
| ID: wpr-106874
ABSTRACT
PURPOSE:
We assessed the correlation between ocular abnormalities and the degree of intraocular pressure (IOP) in the DBA/2J (D2) transgenic mice which were proven to have pigmentary dispersion syndrome and developing glaucoma.METHODS:
Nine-months-old D2 mice were examined with biomicroscopy under anesthesia and measured for IOP by Tono-Pen, Hematoxylin and eosin staining was performed on the eye sections of the mice to analyze differences between the low-grade IOP group and the high-grade IOP group.RESULTS:
Ocular abnormalities including iris pigment loss, iris transillumination, iris stromal atrophy, anterior synechia, thinning of the retina, and ganglion cell loss were found; all of which appeared to be pressure- dependent.CONCLUSIONS:
These results corroborate that both IOP and age might be considered for studies using D2 mice, and suggest that D2 mice are a useful glaucoma model to study the mechanisms of retinal ganglion cell death and to evaluate strategies for neuroprotection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retina
/
Retinal Ganglion Cells
/
Atrophy
/
Mice, Transgenic
/
Transillumination
/
Glaucoma
/
Iris
/
Eosine Yellowish-(YS)
/
Ganglion Cysts
/
Hematoxylin
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2004
Type:
Article
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