A Clinical Study on Malignant Germ Cell Tumor of Ovary / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 910-918, 2005.
Article
in Korean
| WPRIM
| ID: wpr-107175
ABSTRACT
OBJECTIVE:
to evaluate the clinicopathologic characteristics of patients with ovarian malignant germ cell tumor.METHODS:
We reviewed records of women who had malignant germ cell tumors of the ovary from 1991-2000.RESULTS:
Thirty-seven women had surgical resections of malignant ovarian germ cell tumors and most received adjuvant therapy. Twenty-five women (68%) presented with stage I disease, and 12 (32%) had more advanced disease. Histology subtypes were immature teratoma (n=16), dysgerminoma (n=9), yolk sac tumor (n=8), choriocarcinoma (n=2), embryonal carcinoma (n=1), and mixed germ cell tumor (n=1). The frequency of positive tumor markers were aFP, CA-125, beta-hCG, CA 19-9 and LDH in decreasing order. The mean age of the patients at presentation was 23.9 years (4-58). Surgical management of the 32 patients consisted of unilateral oophorectomy, or salpingo-oophorectomy, 1 woman with stage III disease underwent bilateral salpingo-oophorectomy and 4 women underwent total abdominal hysterctomy, bilateral or unilateral adnexectomy. Thirty-two women were treated with adjuvant combination chemotherapy (BEP, VAC, VBP) according to indications. The 5-year survival rate was 100%, and 5-year disease-free rate was 91.8%. Among twelve patients who attempted pregnancy, 8 succeeded in it and delivered normal full term babies.CONCLUSION:
Current therapeutic strategies can allow most women with ovarian malignant germ cell tumors to have conservative surgery without compromising survival and to preserve their reproductive potential.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovary
/
Teratoma
/
Ovariectomy
/
Choriocarcinoma
/
Biomarkers, Tumor
/
Survival Rate
/
Endodermal Sinus Tumor
/
Carcinoma, Embryonal
/
Neoplasms, Germ Cell and Embryonal
/
Drug Therapy
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2005
Type:
Article
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