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The Effects of 5% Imiquimod Cream on Bowen's Disease / 대한피부과학회지
Korean Journal of Dermatology ; : 1410-1416, 2006.
Article in Korean | WPRIM | ID: wpr-107424
ABSTRACT

BACKGROUND:

Imiquimod is an immune response modifier which works as a Toll-like receptor 7 agonist which induces interferon and other cytokines through the innate immune system and stimulates cell-mediated immunity through T cells. Imiquimod has been shown to be efficacious as a topical treatment for variable cutaneous neoplasms including Bowen's disease.

OBJECTIVE:

The purpose of this study was to evaluate the efficacy and safety of 5% imiquimod cream for the treatment of Bowen's disease.

METHODS:

Thirty one lesions from 13 patients with Bowen's disease were treated with 5% imiquimod cream, 3 times per week at night, until complete clearance of lesions had occurred. During the follow-up period, the duration of therapeutic response, clearance rate, side effects and recurrence were recorded. Biopsy specimens from five patients after treatment completion were obtained to confirm tumor clearance.

RESULTS:

Complete clinical response was obtained in 30 lesions (96.8%) from 12 patients, and a partial clinical response was observed in a palmar lesion of 1 patient. The duration of complete response ranged from 4 to 24 weeks, and mean duration was 11.8 weeks. All patients showed mild to moderate local skin reactions such as erythema, erosion, crusting, itching, burning, and pain. No-one experienced systemic adverse effects during topical application. After 3 to 26 months follow-up of the patients who had shown complete clearance, no-one encountered recurrence.

CONCLUSION:

5% imiquimod cream appears to be safe and effective for the treatment of Bowen's disease, and so therefore may be promising future treatment for this condition.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pruritus / Recurrence / Skin / Biopsy / Bowen's Disease / Burns / T-Lymphocytes / Follow-Up Studies / Cytokines / Interferons Type of study: Observational study / Prognostic study Limits: Humans Language: Korean Journal: Korean Journal of Dermatology Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pruritus / Recurrence / Skin / Biopsy / Bowen's Disease / Burns / T-Lymphocytes / Follow-Up Studies / Cytokines / Interferons Type of study: Observational study / Prognostic study Limits: Humans Language: Korean Journal: Korean Journal of Dermatology Year: 2006 Type: Article