Interaction of Magnesium Sulfate with Mivacurium-induced Neuromuscular Block in Rabbits / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 510-517, 1997.
Article
in Korean
| WPRIM
| ID: wpr-107598
ABSTRACT
BACKGROUND:
Magnesium sulfate(MgSO4) has long been used in the treatment of pre-eclampsia and hypertension. Mivacurium was found to undergo hydrolysis by plasma cholinesterase at 70-88% of the rate of succinylcholine. This study has been conducted to evaluate the time course of mivacurium-induced neuromuscular block according to the pretreatment doses of MgSO4 in rabbits.METHODS:
This study was done using a common peroneal nerve-anterior tibialis muscle preparation in sixty adult rabbits. The onset and recovery times of mivacurium(0.16 mg/kg) were evaluated after the infusion of a placebo in group 1, MgSO4 30 mg/kg in group 2, MgSO4 50 mg/kg in group 3 and MgSO4 70 mg/kg in group 4, respectively(n=15 each).RESULTS:
The mean serum concentration of magnesium was 2.4 mEq/L in group 1, 3.3 mEq/L in group 2, 4.3 mEq/L in group 3 and 5.5 mEq/L in group 4, respectively. The mean time from injection of mivacurium to 95% recovery of twitch amplitude was 32.7 min. in group 1, 32.9 min. in group 2, 30.4 min. in group 3 and 33.0 min. in group 4, respectively.CONCLUSIONS:
The results of the present study suggested that the neuromuscular blocking actions of mivacurium are not affected according to the pretreatment doses of MgSO4.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Pre-Eclampsia
/
Succinylcholine
/
Cholinesterases
/
Neuromuscular Blockade
/
Hydrolysis
/
Hypertension
/
Ions
/
Magnesium
/
Magnesium Sulfate
Type of study:
Controlled clinical trial
Limits:
Adult
/
Animals
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1997
Type:
Article
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