Your browser doesn't support javascript.
loading
The critical time of avian leukosis virus subgroup J-mediated immunosuppression during early stage infection in specific pathogen-free chickens
Journal of Veterinary Science ; : 235-241, 2011.
Article in English | WPRIM | ID: wpr-108028
ABSTRACT
The critical time of avian leukosis virus subgroup J (ALV-J)-mediated immunosuppression was determined by body weight, relative immune organ weight, histopathology, and presence of group specific antigen and antibodies in specific pathogen-free (SPF) chickens. CD4+ and CD8+ cell activity in the spleen, total and differential leukocyte counts in blood, and viral RNA levels in spleen were measured. Significant growth suppression was observed in the two ALV-J-infected groups. A strong immune response by infected groups was present in spleen at 2-weeks-of-age, but after 4-weeks-of-age, the response decreased quickly. The thymus and bursa showed persistent immunosuppression until 4-weeks-of-age. Proliferation of fibroblasts and dendritic cells were observed in immune organs at 4- and 5-weeks-of-age. However, the granulocyte cell number was markedly lower in the infected groups than in the control group. In group 1 (day 1 infection) CD4+ cells increased during the second week but significantly decreased during the fourth week, while group 2 (day 7 infection) showed the opposite effect. Viral RNA increased significantly by the fourth week. These data identify 3~4 weeks post-infection as the key time at which the ALV-J virus exerts its immunosuppressive effects on the host.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Poultry Diseases / Spleen / Body Weight / RNA, Viral / Avian Leukosis / Enzyme-Linked Immunosorbent Assay / CD4 Antigens / Chickens / China / CD8 Antigens Limits: Animals Country/Region as subject: Asia Language: English Journal: Journal of Veterinary Science Year: 2011 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Poultry Diseases / Spleen / Body Weight / RNA, Viral / Avian Leukosis / Enzyme-Linked Immunosorbent Assay / CD4 Antigens / Chickens / China / CD8 Antigens Limits: Animals Country/Region as subject: Asia Language: English Journal: Journal of Veterinary Science Year: 2011 Type: Article