Standardization of Skin Irritation Reaction in Korean with Skin Bioengineering Measurement / 대한피부과학회지
Korean Journal of Dermatology
;
: 1440-1447, 2003.
Article
in Korean
| WPRIM
| ID: wpr-108216
ABSTRACT
BACKGROUND:
It is believed that certain skin types of different age, ethnic group may be more susceptible to the effect of skin irritants than others. However, some previous studies found controversies among intra-, inter-individual variation along with the possibility of ethnic differences in irritation reaction.OBJECTIVE:
Thus, it is mandatory to explore the characteristics of irritant skin reaction in young and old Koreans with objective, standardized instrumental measurement techniques.METHOD:
We have investigated the patterns of skin irritation between adolescent group (19 persons, average age 21.3 +/- 2.3) and old group (18 persons, average age 61.0 +/- 3.6) after physicochemical stimuli by using tape strippings (15, 30 times) and 24 hours SLS (sodium rauryl sulfate, 1% 0.5%) patch application with skin bioengineering measurements for color change(erythema index), TEWL(transepidermal water loss), capacitance and dermal microcirculation (Laser Doppler Flowmetry flux).RESULTS:
The intensity of irritation represented by skin bioengineering measurements showed 30 strippings > 1% SLS > 0.5% SLS > 15 strippings, respectively. The younger the less irritation response at different time-course. TEWL, erythema index and microvascular blood distribution (LDF flux) of old group reached the plateau faster and higher than adolescent group. Occlusive patch containing water induced a potential of irritation regardless of age group that might affect early interpretation of skin bioengineering results.CONCLUSION:
Intensity of irritation reaction and its kinetic suggested the role of age-dependent change of skin. The standardization on skin bioengineering measurement techniques along with irritation methods is mandatory to explore further inter-individual differences of irritation reaction in Korean.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rheology
/
Skin
/
Ethnicity
/
Erythema
/
Bioengineering
/
Irritants
/
Microcirculation
Limits:
Adolescent
/
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2003
Type:
Article
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