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Targeting the Transforming Growth Factor-beta Signaling in Cancer Therapy
Biomolecules & Therapeutics ; : 323-331, 2013.
Article in English | WPRIM | ID: wpr-108282
ABSTRACT
TGF-beta pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-beta (TGF-beta) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-beta related functional contexts. This review discusses the molecular mechanism of the TGF-beta pathway and describes the different ways of tumor suppression and promotion by TGF-beta. In the last part of the review, the data on targeting TGF-beta pathway for cancer treatment is assessed. The TGF-beta inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Breast Neoplasms / Transforming Growth Factor beta / Neoplasm Metastasis Language: English Journal: Biomolecules & Therapeutics Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Breast Neoplasms / Transforming Growth Factor beta / Neoplasm Metastasis Language: English Journal: Biomolecules & Therapeutics Year: 2013 Type: Article