Targeting the Transforming Growth Factor-beta Signaling in Cancer Therapy
Biomolecules & Therapeutics
;
: 323-331, 2013.
Article
in English
| WPRIM
| ID: wpr-108282
ABSTRACT
TGF-beta pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-beta (TGF-beta) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-beta related functional contexts. This review discusses the molecular mechanism of the TGF-beta pathway and describes the different ways of tumor suppression and promotion by TGF-beta. In the last part of the review, the data on targeting TGF-beta pathway for cancer treatment is assessed. The TGF-beta inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast Neoplasms
/
Transforming Growth Factor beta
/
Neoplasm Metastasis
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2013
Type:
Article
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