Differential brain angiotensin-II type I receptor expression in hypertensive rats
Journal of Veterinary Science
;
: 291-293, 2011.
Article
in English
| WPRIM
| ID: wpr-108423
ABSTRACT
Blood-borne angiotensin-II (Ang-II) has profound effects in the brain. We tested the hypothesis that Ang-II-dependent hypertension involves differential Ang-II type I (AT1) receptors expression in the subfornical organ (SFO) and the rostral ventrolateral medulla (RVLM). Male Wistar rats were implanted with 14-day osmotic minipump filled with Ang-II (150 ng/kg/min) or saline. AT1 receptor mRNA levels were detected in the SFO and RVLM by reverse transcription-polymerase chain reaction (RT-PCR). Ang-II caused hypertension (134 +/- 10 mmHg vs. 98 +/- 9 mmHg, n = 9, p < 0.05). RT-PCR revealed that Ang-II infusion induced increased AT1 receptor mRNA levels in RVLM and decreased in SFO. Our data suggest that Ang-II-induced hypertension involves differential expression of brain AT1 receptors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Subfornical Organ
/
RNA, Messenger
/
Angiotensin II
/
Medulla Oblongata
/
Signal Transduction
/
Rats, Wistar
/
Reverse Transcriptase Polymerase Chain Reaction
/
Receptor, Angiotensin, Type 1
/
Hypertension
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2011
Type:
Article
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