Serial Measurements of Off-Thyroxine Serum TSH and Thyroglobulin Levels to Predict Local and/or Systemic Metastasis of Papillary Thyroid Cancer after Total Thyroidectomy / 대한갑상선학회지
Journal of Korean Thyroid Association
;
: 148-156, 2012.
Article
in English
| WPRIM
| ID: wpr-10847
ABSTRACT
BACKGROUND AND OBJECTIVES:
Off-thyroxine serum thyroglobulin (Tg) level is important to predict metastatic disease (MD) in papillary thyroid cancer (PTC); however, it is unclear whether a single off-thyroxine Tg level is sufficient for predicting MD. In this study, we determined whether serial measurement of off-thyroxine serum Tg level can predict metastasis in PTC patients after total thyroidectomy. MATERIALS ANDMETHODS:
We enrolled 140 PTC patients in whom serum thyroid-stimulating hormone (TSH) and Tg levels were measured 7 days before radio-iodine (RAI) treatment (TSHA and TgA) and on the day of RAI treatment (TSHB and TgB) with withholding L-thyroxine for 4 weeks before RAI treatment. The values of TSHinc (TSHB-TSHA) and Tginc (TgB-TgA), Tgratio (TgB/TgA), Tginc/TSHinc and Tgratio/TSHinc were calculated. Tginc/TSHinc and Tgratio/TSHinc were tested if those parameters can predict MD in patients with TSHA>30 microIU/mL and TgA30 microIU/mL and TgA<10 ng/mL (MD, 9; non-MD, 34), both Tginc/TSHinc (100%) and Tgratio/TSHinc (89%) had higher sensitivities for predicting MD than TgB (78%).CONCLUSION:
With the increment in serum Tg corrected for the increment in serum TSH, serial measurements of off-thyroxine serum TSH and Tg levels can help predict PTC metastasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroglobulin
/
Thyroid Gland
/
Thyroidectomy
/
Thyroxine
/
Factor IX
/
Thyroid Neoplasms
/
Thyrotropin
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Korean Thyroid Association
Year:
2012
Type:
Article
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