Clinical characteristics of interferon-gamma-inducible protein of 10 kDa in children with wheezing
Allergy, Asthma & Respiratory Disease
;
: 174-180, 2016.
Article
in Korean
| WPRIM
| ID: wpr-108728
ABSTRACT
PURPOSE:
Recent studies have shown that interferon-gamma-inducible protein of 10 kDa (IP-10/CXCL10) levels is increased in acute bronchiolitis and asthma. The aim of this study was to examine the levels of IP-10 in children with wheezing and whether it correlates with other clinical variables.METHODS:
A total of 62 subjects children were hospitalized for lower respiratory tract infection with wheezing and visited the Emergency Department due to an acute exacerbation of asthma. IP-10 levels were measured using enzyme-linked immunosorbent assay in the serum collected at admission. Serum IP-10 levels were evaluated for the relationships with age, sex, blood eosinophils counts, acute phase reactant, allergic sensitization, history of wheezing, and chest X-ray findings.RESULTS:
Age showed a significant negative correlation with serum IP-10 levels (P=0.002). The serum levels of IP-10 were also significantly increased in patients with pneumonic infiltration on X-rays compared to those with normal or hyperinflation (P<0.009). There was no significant difference in the serum IP-10 level according to the other factors, including allergic sensitization.CONCLUSION:
Serum IP-10 is significantly associated with inflammation of the lung and age, but not with allergic inflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory Tract Infections
/
Asthma
/
Thorax
/
Enzyme-Linked Immunosorbent Assay
/
Bronchiolitis
/
Respiratory Sounds
/
Emergency Service, Hospital
/
Eosinophils
/
Chemokine CXCL10
/
Inflammation
Limits:
Child
/
Humans
Language:
Korean
Journal:
Allergy, Asthma & Respiratory Disease
Year:
2016
Type:
Article
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