Type B insulin-resistance syndrome presenting as autoimmune hypoglycemia, associated with systemic lupus erythematosus and interstitial lung disease
The Korean Journal of Internal Medicine
;
: 98-102, 2013.
Article
in English
| WPRIM
| ID: wpr-108737
ABSTRACT
We describe an unusual case of systemic lupus erythematosus with pulmonary manifestations presenting as hypoglycemia due to anti-insulin receptor antibodies. A 38-year-old female suffered an episode of unconsciousness and was admitted to hospital where her blood glucose was found to be 18 mg/dL. During the hypoglycemic episode, her serum insulin level was inappropriately high (2,207.1 pmol/L; normal range, 18 to 173) and C-peptide level was elevated (1.7 nmol/L; normal range, 0.37 to 1.47). Further blood tests revealed the presence of antinuclear antibodies, anti-double-stranded DNA antibodies, and anti-Ro/SSA, anti-La/SSB, anti-ribonucleoprotein, and anti-insulin receptor antibodies. A computed tomography scan of the abdomen, aimed at tumor localization, such as an insulinoma, instead revealed ground-glass opacities in both lower lungs, and no abnormal finding in the abdomen. For a definitive diagnosis of the lung lesion, video-associated thoracoscopic surgery was performed and histopathological findings showed a pattern of fibrotic non-specific interstitial pneumonia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Blood Glucose
/
Insulin Resistance
/
Receptor, Insulin
/
Biomarkers
/
Tomography, X-Ray Computed
/
Autoimmunity
/
Treatment Outcome
/
Lung Diseases, Interstitial
/
Thoracic Surgery, Video-Assisted
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS