4 Case of Rhabdomyolysis due to Doxylamine Intoxication / 대한신장학회잡지
Korean Journal of Nephrology
;
: 494-500, 1999.
Article
in Korean
| WPRIM
| ID: wpr-108778
ABSTRACT
Doxylamine is common over-the-counter sleep preparations & frequently involved in overdoses. The clinical course is dominated by the anticholinergic effects, including central nervous system & autonomic effects. We report 4 cases of suicide attempts in adults where ingestion of the doxylamines were complicated by rhabdomyolysis. They ingested doxylamines variable amount & were carried to emergency department. They complained gastrointestinal or central nervous system symptoms. Gastric lavages & administrations of activated charcoal were done. Creatine phosphok inase levels were normal or markedly elevated on arrival, but peaked several days later. Serum creatinine levels were normal. 99mTc-MDP bone scans were showed increased muscle labelling at the regions of muscle injury. They were treated with hydration, urine alkalinization, & supportive measures in hospital. On considering cause of rhabdomyolysis, our patients did not show any evidence of viral illness or coingestion of other potential myopathic toxins to support a secondary cause of rhabdomyolysis. The mechanism of rhabdomyolysis in cases of doxylamine overdose seems to be a direct toxic effect of the drug on striated muscle, but the exact mechanism is not clear. In all cases where such overdoses are suspected, consideration should be given to obtaining a urinalysis & a creatine phosphokinase level on arrival & creatine phosphokinase levels are carefully followed. Primary detoxication included gastric lavage & administration of activated charcoal. The patient's urine output & renal function should be closely monitored.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rhabdomyolysis
/
Autonomic Agents
/
Suicide
/
Central Nervous System
/
Charcoal
/
Technetium Tc 99m Medronate
/
Urinalysis
/
Creatine
/
Creatine Kinase
/
Creatinine
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
1999
Type:
Article
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