Clearance
Translational and Clinical Pharmacology
;
: 42-45, 2015.
Article
in English
| WPRIM
| ID: wpr-108801
ABSTRACT
This tutorial deals with basic concepts of clearance, the most important parameter in pharmacokinetics but often challenging for students in clinical pharmacology. Its relationships with dose, concentration and elimination rate are discussed using a physical model and examples of commonly used drugs, as well as its physiological aspects pertaining to the blood flow to differing organs. Finally, application of clearance to the calculation of maintenance dose rate and half-life is used to show how it is essential in pharmacotherapy and clinical pharmacology.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology, Clinical
/
Pharmacokinetics
/
Drug Therapy
/
Half-Life
Limits:
Humans
Language:
English
Journal:
Translational and Clinical Pharmacology
Year:
2015
Type:
Article
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