Morphological Features of Metastatic Gastrointestinal Stromal Tumors after Gleevec Treatment: Two Cases Report
Korean Journal of Pathology
;
: 368-373, 2009.
Article
in English
| WPRIM
| ID: wpr-108859
ABSTRACT
We report two patients with metastatic gastrointestinal stromal tumors (GISTs) with a focus on the morphological features related to Gleevec treatment. In case 1, a 50-year-old woman presented with a 1.8 cm metastatic GIST in the liver after resection of a gastric GIST. Majority of the metastatic tumor showed fibrosis and hyalinization after 8 weeks of Gleevec treatment. CD117-positive cells were present in approximately 1% of the overall tumor. In case 2, a 2 cm and 14 cm metastatic liver masses were found in a 54-year-old man who had a rectal GIST. After 4 weeks of Gleevec treatment, metastatic tumors showed a decrease in size on CT scan. The metastatic tumors showed a decrease in number of tumor cells. The hemorrhage, cystic changes, necrosis, and fibrosis made up approximately 90% of the tumor. The morphological features related to Gleevec treatment are important for correct diagnosis and evaluation of tumor response and prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperazines
/
Prognosis
/
Pyrimidines
/
Benzamides
/
Fibrosis
/
Gastrointestinal Stromal Tumors
/
Imatinib Mesylate
/
Hemorrhage
/
Hyalin
/
Liver
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2009
Type:
Article
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