Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Korean Women: A Multicenter Study
Korean Journal of Pathology
;
: 342-350, 2009.
Article
in English
| WPRIM
| ID: wpr-108864
ABSTRACT
Background:
DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing.Methods:
A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing.Results:
Overall HPV positivity was 15.8% and 78.4% in women with normal and abnormal cytology, respectively. High-risk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma.Conclusions:
The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vaginal Smears
/
Population Characteristics
/
DNA
/
Cervix Uteri
/
Mass Screening
/
Prevalence
/
Vaccination
/
Oligonucleotide Array Sequence Analysis
/
Republic of Korea
/
Genotype
Type of study:
Controlled clinical trial
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Korean Journal of Pathology
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS