Expression of P-glycoprotein and Apoptosis in Diffuse Large B-cell Lymphoma
Korean Journal of Pathology
;
: 317-320, 2009.
Article
in Korean
| WPRIM
| ID: wpr-108868
ABSTRACT
BACKGROUND:
Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma which responds well to conventional chemotherapy. However, quite a few patients have a recurrence with more aggressive forms after completion of therapy. Multidrug resistance proteins (MRP) are related to this process in several ways such as cell cycle alteration and modulation of apoptosis.METHODS:
We investigated the expression of P-glycoprotein (Gp), one of the well-known MRP, as well as apoptosis associated proteins in DLBCL. Immunohistochemical staining for Gp, p53, Bcl-2, Ki-67, active caspase 3 and FADD was done in forty DLBCL cases. The association between MRP and apoptosis associated proteins to clinical findings was also tested.RESULTS:
Twenty-nine patients out of 40 (73%) with DLBCL were positive for Gp, and 26 cases (65%) had a strong positive for Gp. Gp expression was stronger in high-grade lesions than in low-grade lesions and was associated to Bcl-2 expression. However, we could not find an adverse impact of Gp expression on patients' overall survival or relapse free survival rate.CONCLUSIONS:
Our study revealed a high frequency of expression for Gp in DLBCL with a possible relationship between the expressions of Gp to apoptosis associated proteins.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
B-Lymphocytes
/
Proteins
/
Cell Cycle
/
Survival Rate
/
Lymphoma, B-Cell
/
Lymphoma, Large B-Cell, Diffuse
/
Apoptosis
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
ATP Binding Cassette Transporter, Subfamily B
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
2009
Type:
Article
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