A Clinical Study of Topical 2% Dorzolamide(Trusopt) as Adjunctive Therapy

ABSTRACT

We investigated the intraocular pressure(IOP) lowering effect and side effects of 2% dorzolamide(Trusopt) as adjunctive therapy in 18 eyes of 11 glaucoma patients and 10 eyes of 10 normal subjects. For those patients who have taken beta-blocker at least 2 weeks in glaucoma or ocular hypertension, we measured IOP before dorzolamide start and after dorzolamide instillation, every 2 hours from 10 AM to 4 PM for 3 weeks and evaluated the side effects. In normal subjects, we Measured the same method of IOP for 2 weeks and evaluated the side effects. In patients with glaucoma or ocular hypertension, mean IOP was lowered 4.4 mmHg after 2% dorzolamide instillation(P0.05). The common side effects were bitter taste, burning sensation, redness, tearing and dryness. Above these results, we think 2% dorzolamide is effective as adjunctive therapy in glaucoma and more follow-up and treatment is needed to establish the fact.