Associated Factors with Parenteral Nutrition Associated Cholestasis in Neonates / 소아외과
Journal of the Korean Association of Pediatric Surgeons
;
: 1-6, 2015.
Article
in Korean
| WPRIM
| ID: wpr-109293
ABSTRACT
PURPOSE:
Long time total parenteral nutrition (TPN) can induce irreversible liver damage. In this study, we investigated the associated factors of parenteral nutrition associated cholestasis (PNAC) in neonates.METHODS:
We retrospectively reviewed 227 neonates (malefemale=110117) those who had received TPN over 2 weeks from March 2010 to February 2014. PNAC was defined as direct bilirubin was higher than 2.0 mg/dL without any cause except TPN.RESULTS:
Overall incidence was 28.6%. PNAC was frequently developed in younger gestational age with lower birth weight. Episodes of sepsis, underlying bronchopulmonary dysplasia, history of necrotizing enterocolitis, and experience of gastrointestinal surgery increase the incidence of PNAC. PNAC was directly associated the duration of TPN and long period to full enteral feeding, reaching 60 and 150 mL/kg/day. Overall mortality rate was 9.7%. It was higher in PNAC group despite PNAC was not the primary cause of death. All survivors were recovered from cholestasis with encourage of enteral nutrition.CONCLUSION:
PNAC in neonate was associated with younger gestational ages and lower birth weights, duration of TPN, or who experienced sepsis, necrotizing enterocolitis, gastrointestinal surgery or bronchopulmonary dysplasia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bilirubin
/
Birth Weight
/
Bronchopulmonary Dysplasia
/
Cholestasis
/
Incidence
/
Retrospective Studies
/
Mortality
/
Cause of Death
/
Gestational Age
/
Enteral Nutrition
Type of study:
Incidence study
/
Observational study
/
Prognostic study
Limits:
Humans
/
Infant, Newborn
Language:
Korean
Journal:
Journal of the Korean Association of Pediatric Surgeons
Year:
2015
Type:
Article
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