Relationship between Allergic Rhinitis and Asthma in High School Students in Korea / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 30-40, 2010.
Article
in Korean
| WPRIM
| ID: wpr-109327
ABSTRACT
PURPOSE:
The aim of this study was to determine whether allergic rhinitis (AR) without asthma is associated with bronchial hyperresponsiveness (BHR) and symptoms of asthma in Korean adolescents.METHODS:
A questionnaire survey was conducted on 724 high school students (males 556; females, 168) from Seoul City. We also performed the lung function test, methacholine challenge test, skin prick test, and allergy-related blood biomarkers. This cross-sectional study was conducted in the subjects excluding current asthmatic patients.RESULTS:
AR (+), BHR (+) patients tended to show a high prevalence of wheeze ever, a high diagnosis rate of asthma ever, low forced expiratory volume in one second (FEV(1)), low forced expiratory flow at the 25% and 75% of pulmonary volume (FEF(25-75%)) high total IgE and frequent sensitizaion to house dust mites compared with AR (-), BHR (-) patients. In atopy AR (+) group, wheeze ever and treatment of asthma during the last 12 months were significantly higher than atopy (-), AR (-) patients or atopy (+), AR (-) patients (P<0.05). In atopy (+), AR (+) patients, BHR and peripheral eosinophil percent were significantly higher than in other patients (P<0.05) and PC(20) was also significantly lower than in other patients (P<0.05).CONCLUSION:
BHR in current AR was associated with FEV(1), FEF(25-75%), total IgE, and sensitization to house dust mites. Current AR was associated with symptoms of asthma, peripheral eosinophilia and BHR, regardless of atopy. This study showed a significant association between allergic rhinitis and asthma or BHR among Korean adolescents. This cross-sectional study supports the concept of 'one airway, one disease' between the AR and asthma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory Function Tests
/
Asthma
/
Immunoglobulin E
/
Skin Tests
/
Biomarkers
/
Rhinitis
/
Rhinitis, Allergic, Perennial
/
Forced Expiratory Volume
/
Prevalence
/
Cross-Sectional Studies
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adolescent
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Pediatric Allergy and Respiratory Disease
Year:
2010
Type:
Article
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