Omega 3 fatty acids as a host modulator in chronic periodontitis patients: a randomised, double-blind, palcebo-controlled, clinical trial
Journal of Periodontal & Implant Science
;
: 25-32, 2014.
Article
in English
| WPRIM
| ID: wpr-109411
ABSTRACT
PURPOSE:
Periodontitis is an infectious disease caused predominantly by gram-negative anerobes. The host inflammatory response to these bacteria causes alveolar bone loss that is characterized as periodontitis. Omega-3 fatty acids (omega-3 FAs) have anti-inflammatory properties, thus have been used to treat some chronic inflammatory diseases such as cardiovascular disease and rheumatoid arthritis. We aimed to evaluate the effect of dietary supplementation with omega-3 FAs as a host modulating agent in patients with chronic periodontitis.METHODS:
Sixty otherwise healthy subjects with moderate and severe chronic periodontitis were enrolled in our randomised, double-blind, placebo-controlled trial. The control group (CG, n=30) was treated with scaling and root planing (SRP) and given a placebo; the treatment group (TG, n=30) was treated with SRP and dietary supplementation of omega-3 FAs (one 300 mg tablet daily for 12 weeks). Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated in all patients at baseline, a 6-week and 12-week period after treatment.RESULTS:
A significant reduction in the gingival index, sulcus bleeding index, pocket depth, and clinical attachment level was found in the TG compared to the CG at a 12-week period. However, no statistically significant changes in serum CRP levels were found.CONCLUSIONS:
Our findings suggest that omega-3 FAs can successfully reduce gingival inflammation, pocket depth, and attachment level gain. Dietary supplementation with omega-3 FAs may have potential benefits as a host modulatory agent in the prevention and/or adjunctive management of chronic periodontitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontitis
/
Arthritis, Rheumatoid
/
Bacteria
/
C-Reactive Protein
/
Cardiovascular Diseases
/
Fatty Acids, Omega-3
/
Periodontal Index
/
Communicable Diseases
/
Alveolar Bone Loss
/
Root Planing
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Journal of Periodontal & Implant Science
Year:
2014
Type:
Article
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