Demyelination of neurofilament protein 200 immune positive never fibers in human pulp
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 360-365, 2010.
Article
in Korean
| WPRIM
| ID: wpr-109511
ABSTRACT
INTRODUCTION:
Mammalian tooth pulp is densely innervated by sensory nerves that are mostly C fibers and A delta fibers. However, there is evidence suggesting that many unmyelinated axons in the pulp are in fact parent meylinated axons. MATERIALS ANDMETHODS:
The pulp was removed from healthy premolars and 3rd molars extracted from juveniles and adults undergoing orthodontic treatment, and immunohistochemical staining were applied with NPF200 antibodies, which specifically dye myelinated axons. The specimens underwent an electron microscopy examination with diaminobenzidine (DAB) immunostaining after observation and analysis by fluorescence and confocal laser scanning microscopy.RESULTS:
The NPF200 immuno-positive axons in the radicular pulp areas were observed as bundles of many nerve fibers. Many small bundles were formed with fewer axons when firing to the coronal pulp areas and then reachrd a different direction.CONCLUSION:
Myelinated fibers innervated to the dental pulp maintain their myelins in the radicular portion, but these fibers lost myelins in the coronal portion. Afterthe loss of myelin, the size of the axoplasm also decreased.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parents
/
Axons
/
Tooth
/
Bicuspid
/
Microscopy, Electron
/
Demyelinating Diseases
/
Nerve Fibers, Unmyelinated
/
Dental Pulp
/
Fires
/
Fluorescence
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2010
Type:
Article
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