Esophageal Acid Clearance During Random Swallowing Is Faster in Patients with Barrett's Esophagus Than in Healthy Controls
Journal of Neurogastroenterology and Motility
;
: 630-642, 2016.
Article
in English
| WPRIM
| ID: wpr-109537
ABSTRACT
BACKGROUND/AIMS:
Impaired esophageal acid clearance may be a contributing factor in the pathogenesis of Barrett’s esophagus. However, few studies have measured acid clearance as such in these patients. In this explorative, cross-sectional study, we aimed to compare esophageal acid clearance and swallowing rate in patients with Barrett’s esophagus to that in healthy controls.METHODS:
A total of 26 patients with histology-confirmed Barrett’s esophagus and 12 healthy controls underwent (1) upper endoscopy, (2) an acid clearance test using a pH-impedance probe under controlled conditions including controlled and random swallowing, and (3) an ambulatory pH-impedance measurement.RESULTS:
Compared with controls and when swallowing randomly, patients cleared acid 46% faster (P = 0.008). Furthermore, patients swallowed 60% more frequently (mean swallows/minute 1.90 ± 0.74 vs 1.19 ± 0.58; P = 0.005), and acid clearance time decreased with greater random swallowing rate (P 0.3).CONCLUSIONS:
More frequent swallowing and thus faster acid clearance in Barrett’s esophagus may constitute a protective reflex due to impaired mucosal integrity and possibly acid hypersensitivity. Despite these reinforced mechanisms, acid clearance ability seems to be overthrown by repeated, retrograde acid reflux, thus resulting in increased esophageal acid exposure and consequently mucosal changes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reflex
/
Barrett Esophagus
/
Gastroesophageal Reflux
/
Cross-Sectional Studies
/
Electric Impedance
/
Deglutition
/
Endoscopy
/
Esophagus
/
Esophageal pH Monitoring
/
Hypersensitivity
Type of study:
Controlled clinical trial
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Neurogastroenterology and Motility
Year:
2016
Type:
Article
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