Serial Follow-up of White Matter Connectivity in a Patient with Progressive Multifocal Leukoencephalopathy Presenting Clinical Improvement
Journal of the Korean Neurological Association
;
: 347-351, 2011.
Article
in Korean
| WPRIM
| ID: wpr-109591
ABSTRACT
Progressive multifocal leukoencephalopathy (PML) is a fatal disease that is characterized by progressive demyelination of the cerebral white matter due to JC viral infection. We report serial magnetic resonance spectroscopy (MRS) and tractography changes in a patient with PML. After a three-cycle treatment with cidofovir and cytarabine, the patient exhibited remarkable improvements in motor and cognitive functions. Follow-up MRS and tractography revealed regeneration of the white-matter fibers. This is the first consecutive neuroimaging study showing improvements in neurological symptoms using MRS and tractography.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
Magnetic Resonance Spectroscopy
/
Follow-Up Studies
/
Leukoencephalopathy, Progressive Multifocal
/
Demyelinating Diseases
/
Cytarabine
/
Cytosine
/
Neuroimaging
/
Organophosphonates
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2011
Type:
Article
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