Modifying Effect of Indole-3-carbinol on the Rat Colon Carcinogenesis / 한국실험동물학회지
Laboratory Animal Research
;
: 339-343, 2010.
Article
in Korean
| WPRIM
| ID: wpr-109629
ABSTRACT
Indole-3-carbinol (I3C) found in various cruciferous vegetables has been shown to exert anti-carcinogenic activity in several target organs. Our study was conducted to assess the modifying effect of I3C on the development of colon tumor induced by azoxymethane (AOM). Eighty-seven male F344 rats were divided into 5 groups and were treated with AOM followed by I3C 100 or 300 ppm, AOM alone, I3C alone, and non-treatment, respectively. The animals were subcutaneously injected with AOM. Then diet containing I3C were fed to the rats for 37 weeks. All rats were sacrificed at 40 weeks. Liver and kidney weights of rats treated with I3C at doses of 100 or 300 ppm were significantly increased compared to those of the control group. Colonic tumor incidence and multiplicity of rats treated with I3C at doses of 100 and 300 ppm were not significant compared to those of AOM alone group. In the pathological examination, most of tumors were classified with adenoma and adenocarcinoma in the small and large intestine. These results demonstrated that I3C may have not chemopreventive effect on the rat colon carcinogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rats, Inbred F344
/
Azoxymethane
/
Vegetables
/
Weights and Measures
/
Adenocarcinoma
/
Adenoma
/
Incidence
/
Colon
/
Diet
/
Indoles
Type of study:
Incidence study
/
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Laboratory Animal Research
Year:
2010
Type:
Article
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