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Is There a Role for Adjuvant Therapy in R0 Resected Gallbladder Cancer?: A Propensity Score-Matched Analysis / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 1274-1285, 2016.
Article in English | WPRIM | ID: wpr-109749
ABSTRACT

PURPOSE:

The purpose of this study is to assess the role of adjuvant therapy in stage I-III gallbladder cancer (GBC) patients who have undergone R0 resection. MATERIALS AND

METHODS:

Clinical data were collected on 441 consecutive patients who underwent R0 resection for stage I-III GBC. Eligible patients were classified into adjuvant therapy and surveillance only groups. Propensity score matching (PSM) between the two groups was performed, adjusting clinical factors.

RESULTS:

In total, 84 and 279 patients treated with adjuvant therapy and followed up with surveillance only, respectively, were included in the analysis. Before PSM, the 5-year relapse-free survival (RFS) rate was lower in the adjuvant therapy group than in the surveillance only group (50.8% vs. 74.8%, p < 0.001), although there was no statistically significant difference in the 5-year overall survival (OS) rate (66.2% vs. 79.5%, p=0.089). After the PSM, baseline characteristics became comparable and there were no differences in the 5-year RFS (50.8% vs. 64.8%, p=0.319) and OS (66.2% vs. 70.4%, p=0.703) rates between the two groups.

CONCLUSION:

The results suggest that fluoropyrimidine-based adjuvant therapy is not indicated in stage I-III GBC patients who have undergone R0 resection.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Chemotherapy, Adjuvant / Propensity Score / Chemoradiotherapy, Adjuvant / Gallbladder / Gallbladder Neoplasms Limits: Humans Language: English Journal: Cancer Research and Treatment Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Chemotherapy, Adjuvant / Propensity Score / Chemoradiotherapy, Adjuvant / Gallbladder / Gallbladder Neoplasms Limits: Humans Language: English Journal: Cancer Research and Treatment Year: 2016 Type: Article