Venous Invasion in Colorectal Cancer: Impact of Morphologic Findings on Detection Rate / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 1222-1228, 2016.
Article
in English
| WPRIM
| ID: wpr-109754
ABSTRACT
PURPOSE:
Venous invasion (VI) is widely accepted as a poor prognostic factor in colorectal cancer (CRC), and is indicated as a high-risk factor determining the use of adjuvant chemotherapy in CRC. However, there is marked interobserver and intraobserver variability in VI identification and marked variability in the real prevalence of VI in CRC. MATERIALS ANDMETHODS:
We investigated the detection rate of VI in 93 consecutive cases of T3 or T4 CRC based on the following original pathology report, review of hematoxylin and eosin (H&E) slides with attention to the "protruding tongue" and "orphan arteriole" signs, and elastic stain as the gold standard.RESULTS:
Overall, the detection rate of VI was significantly increased as follows 14/93 (15.1%) in the original pathology report, 38/93 (40.9%) in review of H&E slides with attention to the "protruding tongue" and "orphan arteriole" signs, and 45/93 (48.4%) using elastic stain. VI detection based on morphologic features showed 77.8% sensitivity and 91.1% specificity and showed a linear correlation (Spearman correlation coefficient, 0.727; p < 0.001) with VI detected by elastic stain. In addition, improved agreement between detection methods (detection on the basis of morphologic features, κ=0.719 vs. original pathology report, κ=0.318) was observed using kappa statistics.CONCLUSION:
Slide review with special attention to the "protruding tongue" and "orphan arteriole" signs could be used for better identification of VI in CRC in routine surgical practice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Rectum
/
Veins
/
Colorectal Neoplasms
/
Adenocarcinoma
/
Observer Variation
/
Prevalence
/
Sensitivity and Specificity
/
Elastin
/
Chemotherapy, Adjuvant
Type of study:
Diagnostic study
/
Prevalence study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Cancer Research and Treatment
Year:
2016
Type:
Article
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