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Contrast-Induced Nephropathy in Patients Undergoing Intravenous Contrast-Enhanced Computed Tomography in Korea: A Multi-Institutional Study in 101487 Patients
Korean Journal of Radiology ; : 456-463, 2014.
Article in English | WPRIM | ID: wpr-109966
ABSTRACT

OBJECTIVE:

To evaluate the prevalence of known risk factors for contrast-induced nephropathy (CIN) and their association with the actual occurrence of CIN in patients undergoing intravenous contrast-enhanced computed tomography (CECT) in Korea. MATERIALS AND

METHODS:

Patients who underwent CECT in 2008 were identified in the electronic medical records of 16 tertiary hospitals of Korea. Data on demographics, comorbidities, prescriptions and laboratory test results of patients were collected following a standard data extraction protocol. The baseline renal function was assessed using the estimated glomerular filtration rate (eGFR). We identified the prevalence of risk factors along the eGFR strata and evaluated their influence on the incidence of CIN, defined as a 0.5 mg/dL or 25% increase in serum creatinine after CECT.

RESULTS:

Of 432425 CECT examinations in 272136 patients, 140838 examinations in 101487 patients met the eligibility criteria for analysis. The mean age of the participants was 57.9 +/- 15.5 years; 25.1% of the patients were older than 70 years. The prevalence of diabetes mellitus was 11.9%, of hypertension 13.7%, of gout 0.55% and of heart failure was 1.7%. Preventive measures were used in 40238 CECT examinations (28.6%). The prevalence of risk factors and use of preventive measures increased as the renal function became worse. A CIN was occurred after 3103 (2.2%) CECT examinations, revealing a significant association with decreased eGFR, diabetes mellitus, and congestive heart failure after adjustment.

CONCLUSION:

Risk factors for CIN are prevalent among the patients undergoing CECT. Preventive measures were seemingly underutilized and a system is needed to improve preventive care.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Tomography, X-Ray Computed / Comorbidity / Incidence / Prevalence / Risk Factors / Contrast Media / Republic of Korea / Glomerular Filtration Rate / Kidney Diseases Type of study: Etiology study / Incidence study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Korean Journal of Radiology Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tomography, X-Ray Computed / Comorbidity / Incidence / Prevalence / Risk Factors / Contrast Media / Republic of Korea / Glomerular Filtration Rate / Kidney Diseases Type of study: Etiology study / Incidence study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Korean Journal of Radiology Year: 2014 Type: Article