The efficacy of nuchal translucency with free beta-hCG, PAPP-A as a screening test for detection of chromosomal anomaly in the first trimester of pregnancy / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1091-1096, 2001.
Article
in Korean
| WPRIM
| ID: wpr-110125
ABSTRACT
OBJECTIVES:
The aim of this study is to determine the efficacy of nuchal translucency in combination with free beta-hCG, PAPP-A in the first trimester screening for chromosomal anomaly in general population.METHODS:
Between April 1998 and December 1999, we evaluated 263 pregnant women undergoing first trimester screening test for fetal chromosomal anomaly using nuchal translucency combined with free beta-hCG, PAPP-A. We confirmed the pregnancy outcomes through chorionic villi sampling, amniocentesis or term delivery. We excluded 15 pregnant women because of their obscure pregnancy outcomes. Statistical analysis was considered significant when P value was lower than 0.05.RESULTS:
With a risk cut-off of 1 in 400, 24 pregnancies(9.7%) of 248 cases were screen positive and 224 pregnancies(90.3%) were screen negative. 2 cases of Down syndrome and 1 case of Turner syndrome were detected in screen positive group. No chromosomal anomalies were detected in screen negative group.CONCLUSION:
In this study, 8.57% of false positive rate and 12.5% of positive predictive value were obtained in the first trimester screening for chromosomal anomaly using nuchal translucency and serum markers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnancy-Associated Plasma Protein-A
/
Pregnancy Trimester, First
/
Turner Syndrome
/
Pregnancy Outcome
/
Biomarkers
/
Chorionic Villi Sampling
/
Mass Screening
/
Down Syndrome
/
Pregnant Women
/
Nuchal Translucency Measurement
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2001
Type:
Article
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