Pre-Operative Perfusion Skewness and Kurtosis Are Potential Predictors of Progression-Free Survival after Partial Resection of Newly Diagnosed Glioblastoma
Korean Journal of Radiology
;
: 117-126, 2016.
Article
in English
| WPRIM
| ID: wpr-110205
ABSTRACT
OBJECTIVE:
To determine whether pre-operative perfusion skewness and kurtosis derived from normalized cerebral blood volume (nCBV) histograms are associated with progression-free survival (PFS) of patients after partial resection of newly diagnosed glioblastoma. MATERIALS ANDMETHODS:
A total of 135 glioblastoma patients who had undergone partial resection of tumor (resection of < 50% of pre-operative tumor volume or surgical biopsy) confirmed with immediate postsurgical MRI and examined with both conventional MRI and dynamic susceptibility contrast (DSC) perfusion MRI before the surgery were retrospectively reviewed in this study. They had been followed up post-surgical chemoradiotherapy for tumor progression. Using histogram analyses of nCBV derived from pre-operative DSC perfusion MRI, patients were sub-classified into the following four groups positive skewness and leptokurtosis (group 1); positive skewness and platykurtosis (group 2); negative skewness and leptokurtosis (group 3); negative skewness and platykurtosis (group 4). Kaplan-Meier analysis and multivariable Cox proportional hazards regression analysis were performed to determine whether clinical and imaging covariates were associated with PFS or overall survival (OS) of these patients.RESULTS:
According to the Kaplan-Meier method, median PFS of group 1, 2, 3, and 4 was 62, 51, 39, and 41 weeks, respectively, with median OS of 82, 77, 77, and 72 weeks, respectively. In multivariable analyses with Cox proportional hazards regression, pre-operative skewness/kurtosis pattern (hazard ratio 2.98 to 4.64; p < 0.001), Karnofsky performance scale score (hazard ratio 1.04; p = 0.003), and post-operative tumor volume (hazard ratio 1.04; p = 0.02) were independently associated with PFS but not with OS.CONCLUSION:
Higher skewness and kurtosis of nCBV histogram before surgery were associated with longer PFS in patients with newly diagnosed glioblastoma after partial tumor resection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Image Processing, Computer-Assisted
/
Brain Neoplasms
/
Magnetic Resonance Imaging
/
Image Interpretation, Computer-Assisted
/
Statistical Distributions
/
Regression Analysis
/
Retrospective Studies
/
Glioblastoma
/
Disease-Free Survival
/
Tumor Burden
Type of study:
Diagnostic study
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Observational study
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Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Radiology
Year:
2016
Type:
Article
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